Advancements Through Collaboration

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Our Mission

To challenge current paradigms and rapidly advance therapies that are globally accessible and transformative for children and young adults with brain tumors.


The Pediatric Neuro-Oncology Consortium (PNOC) is an international consortium with centers within the United States, Europe, Asia and Australia. We are dedicated to bringing new therapies to children and young adults with brain tumors. Our goal is to improve outcomes by translating the latest findings in brain tumor biology into better treatments for these children.

Advances & Updates

Nov 20


PNOC001: Phase II Study of Everolimus For Recurrent or Progressive Low-Grade Gliomas in Children


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Feb 03

Machine learning to identify LGG subgroups

Our Imaging working group looks at how an unsupervised machine learning approach could review and...

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Research Groups

In 2019, PNOC established disease specific “working groups” with the main intent to bring clinicians, scientists, philanthropy, and families together to enhance clinical trial development and cultivate the most comprehensive correlative studies for each PNOC trial. The working groups use the resources of the Children’s Brain Tumor Network (CBTN) biorepository to help translate ideas about the biology of these tumors into clinical trials to be conducted within PNOC. Clinical and laboratory scientists focus on diseases with high-unmet need and identify gaps and opportunities to change quality and overall outcomes of those patients. Advocacy/philanthropic and family groups are themselves invited to become a part of the strategy, participating on the working group calls/meetings, and to bring their important voice to the discussion.  These interactions have fostered important discussions that support the development and funding of innovative trials.

Working group focus areas include: Low grade Glioma, Diffuse Midline Glioma/High grade Glioma, Medulloblastoma, Atypical Teratoid Rhabdoid Tumors (ATRT), Craniopharyngioma, Ependymoma, Germ Cell Tumors, Immunotherapy, Imaging, and DEI (Diversity, Equity, and Inclusion).

The Organizations and Individuals That Make our Work Possible

PNOC is incredibly grateful for the support from individuals, families and foundations. So many have been affected by cancer, and even pediatric brain cancer, and want to give back. The support via financial contributions, input and perspective on our Research Groups, and championing for pediatric brain cancer at the federal level, invigorates all PNOC members to keep moving the research forward.