Advancements Through Collaboration
Working to understand how brain tumors develop in children and identify personalized treatment strategies.
The Pacific Pediatric Neuro-Oncology Consortium (PNOC) is an international consortium with centers within the United States, Europe, Asia and Australia. We are dedicated to bringing new therapies to children and young adults with brain tumors. Our goal is to improve outcomes by translating the latest findings in brain tumor biology into better treatments for these children.
For Patients and Families Hope for Children Fighting Disease
Patients and families are what drive us. Browse through to find information about our clinical trials or the neuro-oncology centers we work with.
For Foundations & Supporters Verifiable results and Sucesses
PNOC relies on our foundation and family supporters to do our work. Learn how you can get connected to PNOC, and our particular areas of research and focus.
For Researchers & Clinicians Collaboration and Real-Time Insights
We invite researchers and clinicians from across the globe to collaborate with us, either via a working group, particular treatment concept, or full membership.
Advances & Updates
Machine learning to identify LGG subgroups
PNOC003 publication in AACR!
PNOC003, biology-driven study of DIPG, published
Dr. Prados on Making Waves
Research Groups
In 2019, PNOC established disease specific “working groups” with the main intent to bring clinicians, scientists, philanthropy, and families together to enhance clinical trial development and cultivate the most comprehensive correlative studies for each PNOC trial. The working groups use the resources of the Children’s Brain Tumor Network (CBTN) biorepository to help translate ideas about the biology of these tumors into clinical trials to be conducted within PNOC. Clinical and laboratory scientists focus on diseases with high-unmet need and identify gaps and opportunities to change quality and overall outcomes of those patients. Advocacy/philanthropic and family groups are themselves invited to become a part of the strategy, participating on the working group calls/meetings, and to bring their important voice to the discussion. These interactions have fostered important discussions that support the development and funding of innovative trials.
Working group focus areas include: Low grade Glioma, Diffuse Midline Glioma/High grade Glioma, Medulloblastoma, Atypical Teratoid Rhabdoid Tumors (ATRT), Craniopharyngioma, Ependymoma, Germ Cell Tumors, Immunotherapy, Imaging, and DEI (Diversity, Equity, and Inclusion).
The Organizations and Individuals That Make our Work Possible
PNOC is incredibly grateful for the support from individuals, families and foundations. So many have been affected by cancer, and even pediatric brain cancer, and want to give back. The support via financial contributions, input and perspective on our Research Groups, and championing for pediatric brain cancer at the federal level, invigorates all PNOC members to keep moving the research forward.